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Multifunctional, Biocompatible and pH-Responsive Carbon Nanotube- and Graphene Oxide/Tectomer Hybrid Composites and Coatings

Lookup NU author(s): Dr Shayan SeyedinORCiD

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Abstract

Here we present a route for non-covalent functionalization of carboxylated multi-walled carbon nanotubes and graphene oxide with novel two-dimensional peptide assemblies. We show that self-assembled amino-terminated biantennary and tetraantennary oligoglycine peptides (referred to as tectomers) effectively coat carboxylated multi-walled carbon nanotubes and also strongly interact with graphene oxide due to electrostatic interactions and hydrogen bonding as the driving force, respectively. The resulting hybrids can be made into free-standing conducting composites or applied in the form of thin, pH-switchable bioadhesive coatings onto graphene oxide fibers. Monitoring of cell viability of pancreatic cell lines, seeded on those CNT hybrids, show that they can be used as two- and three-dimensional scaffolds to tissue engineer tumour models for studying ex vivo the tumour development and response to treatment. This highly versatile method in producing pH-responsive hybrids and coatings offers an attractive platform for a variety of biomedical applications and for the development of functional materials such as smart textiles, sensors and bioelectronic devices.

Publication metadata

Author(s): Garriga R, Jurewicz I, Seyedin S, Bardi N, Totti S, Matta-Domjan B, Velliou EG, Alkhorayef MA, Cebolla VL, Razal JM, Dalton AB, Muñoz E

Publication type: Article

Publication status: Published

Journal: Nanoscale

Year: 2017

Volume: 9

Issue: 23

Pages: 7791–7804

Print publication date: 21/06/2017

Online publication date: 03/02/2017

Acceptance date: 02/02/2017

ISSN (electronic): 2040-3372

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/C6NR09482A

DOI: 10.1039/C6NR09482A

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