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Lookup NU author(s): Professor Yujiang WangORCiD, Nishant Sinha, Gabrielle Schroeder, Dr Sriharsha Ramaraju, Professor Peter TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against EpilepsyObjective: Predicting postoperative seizure freedom using functional correlation networks derived from interictal intracranial electroencephalography (EEG) has shown some success. However, there are important challenges to consider: (1) electrodes physically closer to each other naturally tend to be more correlated, causing a spatial bias; (2) implantation location and number of electrodes differ between patients, making cross-subject comparisons difficult; and (3) functional correlation networks can vary over time but are currently assumed to be static. Methods: In this study, we address these three challenges using intracranial EEG data from 55 patients with intractable focal epilepsy. Patients additionally underwent preoperative magnetic resonance imaging (MRI), intraoperative computed tomography, and postoperative MRI, allowing accurate localization of electrodes and delineation of the removed tissue. Results: We show that normalizing for spatial proximity between nearby electrodes improves prediction of postsurgery seizure outcomes. Moreover, patients with more extensive electrode coverage were more likely to have their outcome predicted correctly (area under the receiver operating characteristic curve > 0.9, P « 0.05) but not necessarily more likely to have a better outcome. Finally, our predictions are robust regardless of the time segment analyzed. Significance: Future studies should account for the spatial proximity of electrodes in functional network construction to improve prediction of postsurgical seizure outcomes. Greater coverage of both removed and spared tissue allows for predictions with higher accuracy.
Author(s): Wang Y, Sinha N, Schroeder GM, Ramaraju S, McEvoy AW, Miserocchi A, de Tisi J, Chowdhury FA, Diehl B, Duncan JS, Taylor PN
Publication type: Article
Publication status: Published
Journal: Epilepsia
Year: 2020
Volume: 61
Issue: 7
Pages: 1417-1426
Print publication date: 01/07/2020
Online publication date: 26/06/2020
Acceptance date: 21/05/2020
Date deposited: 03/11/2020
ISSN (print): 0013-9580
ISSN (electronic): 1528-1167
Publisher: Blackwell Publishing Inc.
URL: https://doi.org/10.1111/epi.16580
DOI: 10.1111/epi.16580
PubMed id: 32589284
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