Toggle Main Menu Toggle Search

Open Access padlockePrints

Prophylactic Negative Pressure Wound Therapy in Closed Abdominal Incisions: A Meta-analysis of Randomised Controlled Trials

Lookup NU author(s): Sanjay PandanaboyanaORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2019, Société Internationale de Chirurgie.Introduction: Negative pressure wound therapy (NPWT) may prevent subcutaneous fluid accumulation in a closed wound and subsequently reduce surgical site infections (SSI). This meta-analysis aimed to determine the effect of prophylactic NPWT on SSI incidence following abdominal surgery. Methods: A systematic search of MEDLINE and EMBASE databases was performed using PRISMA methodology. All randomised trials reporting the use of NPWT in closed abdominal incisions were included, regardless of the type of operation. The primary outcome measure was the incidence of SSI, stratified by superficial and deep and organ/space infections. Secondary outcomes were wound dehiscence and length of hospital stay. Results: Ten randomised trials met the inclusion criteria (five Caesarean, five midline laparotomy). The use of NPWT reduced overall SSI (11.6% vs. 16.7%, RR 0.67, 95% CI 0.48–0.95, p = 0.02). The rate of superficial SSI rate was also reduced (6.3% vs. 11.3%, RR 0.57, 95% CI 0.35–0.94, p = 0.03). There was no effect on deep or organ/space SSI (3.2% vs. 4.2%, RR 0.77, 95% CI 0.51–1.18, p = 0.23), wound dehiscence (9.7% vs. 10.9%, RR 0.92, 95% CI 0.69–1.21, p = 0.54), or length of hospital stay (MD 0.06 days, 95% CI–0.11 to 0.23, p = 0.51). Conclusions: Prophylactic use of NPWT may reduce the incidence of superficial SSI in closed abdominal incisions but has no effect on deep or organ space SSI.

Publication metadata

Author(s): Wells CI, Ratnayake CBB, Perrin J, Pandanaboyana S

Publication type: Review

Publication status: Published

Journal: World Journal of Surgery

Year: 2019

Volume: 43

Issue: 11

Pages: 2779-2788

Print publication date: 01/11/2019

Online publication date: 08/08/2019

Acceptance date: 02/04/2016

ISSN (print): 0364-2313

ISSN (electronic): 1432-2323

Publisher: Springer New York LLC


DOI: 10.1007/s00268-019-05116-6

PubMed id: 31396673