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Impact of preoperative sarcopenia on postoperative outcomes following pancreatic resection: A systematic review and meta-analysis

Lookup NU author(s): Sanjay PandanaboyanaORCiD


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© 2018 IAP and EPCBackground: Morphometric analysis of sarcopenia has garnered interest due to its putative role in predicting outcomes following surgery for a variety of pathologies, including resection for pancreatic disease. However, there are no standard recommendations on whether sarcopenia is a clinically relevant predictor of outcomes in this setting. The aim of this study was to review the prognostic impact of preoperatively diagnosed sarcopenia on postoperative outcomes following pancreatic resection. Methods: A systematic review of published literature was performed using PRISMA guidelines, and included a search of PubMed, MEDLINE and SCOPUS databases until May 2018. Results: Thirteen studies, including 3608 patients, were included. There was a significant increase in the mean duration of post-operative hospital stay (mean difference of 0.73 days, CI: 0.06–1.40, P = 0.033), there was no difference in the postoperative outcomes, including: clinically relevant postoperative pancreatic fistula, delayed gastric emptying, post-operative bile leak, surgical site infection, significant morbidity and overall morbidity. Conclusion: Preoperative sarcopenia is associated with prolonged hospital stay after pancreatic surgery. However, sarcopenia does not appear to be a significant negative predictive factor in postoperative morbidity although study heterogeneity and risk of bias limit the strength of these conclusions.

Publication metadata

Author(s): Ratnayake CB, Loveday BP, Shrikhande SV, Windsor JA, Pandanaboyana S

Publication type: Review

Publication status: Published

Journal: Pancreatology

Year: 2018

Volume: 18

Issue: 8

Pages: 996-1004

Print publication date: 01/12/2018

Online publication date: 27/09/2018

Acceptance date: 26/09/2018

ISSN (print): 1424-3903

ISSN (electronic): 1424-3911

Publisher: Elsevier B.V.


DOI: 10.1016/j.pan.2018.09.011

PubMed id: 30287167