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Lookup NU author(s): Professor Sanjay PandanaboyanaORCiD
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© 2015 Steunstichting ESOT.Summary This meta-analysis aimed to compare outcomes following bile duct reconstruction in patients with primary sclerosing cholangitis (PSC) undergoing liver transplantation depending on whether duct-to-duct or Roux-en-Y anastomosis was utilized. An electronic search was performed of the MEDLINE, EMBASE, PubMed databases using both subject headings (MeSH) and truncated word searches. Pooled risk ratios and mean difference were calculated using the fixed-effects and random-effects models for meta-analysis. Ten studies including 910 patients met the inclusion criteria. There was no difference in the overall incidence of biliary strictures between the two groups [odds ratio (OR) 1.06 (0.68, 1.66); (P = 0.80)]. The anastomotic stricture rate was similar, [OR 1.18 (0.56, 2.50); (P = 0.67)]. Ascending cholangitis was higher in the Roux-en-Y group [OR 2.91 (1.17, 7.23); (P = 0.02)]. Anastomotic bile leak rates, graft survival, PSC recurrence and number of patients diagnosed with cholangiocarcinoma following transplantation were comparable between both groups. Duct-to-duct and Roux-en-Y reconstruction had comparable outcomes. Both techniques are associated with similar incidence of biliary stricture. The bilioenteric reconstruction was associated with a higher risk of cholangitis. The incidence of de novo cholangiocarcinoma was similar in both groups. Duct-to-duct reconstruction should be considered when feasible in patients with PSC.
Author(s): Pandanaboyana S, Bell R, Bartlett AJ, McCall J, Hidalgo E
Publication type: Article
Publication status: Published
Journal: Transplant International
Year: 2015
Volume: 28
Issue: 4
Pages: 485-491
Print publication date: 04/03/2015
Online publication date: 03/01/2015
Acceptance date: 24/12/2014
ISSN (print): 0934-0874
ISSN (electronic): 1432-2277
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/tri.12513
DOI: 10.1111/tri.12513
PubMed id: 25557556
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