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Meta-analysis of antecolic versus retrocolic gastric reconstruction after a pylorus-preserving pancreatoduodenectomy

Lookup NU author(s): Sanjay PandanaboyanaORCiD


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© 2014 International Hepato-Pancreato-Biliary Association.Introduction Delayed gastric emptying (DGE) is a common complication after a pylorus-preserving pancreatoduodenectomy (PPPD) and is associated with significant morbidity. This study determines whether DGE is affected by antecolic (AC) or retrocolic (RC) reconstruction after a PPPD. Method An electronic search was performed of the MEDLINE, EMBASE and PubMed databases to identify all articles related to this topic. Pooled risk ratios (RR) were calculated for categorical outcomes, and mean differences (MD) for secondary continuous outcomes using the fixed-effects and random-effects models for meta-analysis. Results Nine studies including 878 patients met the inclusion criteria. DGE was lower with an AC reconstruction RR 0.31 [0.12, 0.78] Z = 2.47 (P = 0.010). Length of stay (LOS) MD -4 days [-7.63, -1.14] Z = 2.65 (P = 0.008) and days to commence a solid diet MD -5 days [-6.63, -3.15] Z = 5.50 (P ≤ 0.000) were also significantly in favour of the AC group. There was no difference in the incidence of pancreatic fistula, intra-abdominal collection/bile leak or mortality between the two groups. Conclusion AC reconstruction after PPPD is associated with a lower incidence of DGE. Time to oral intake was significantly shorter with AC reconstruction, with a reduced hospital stay.

Publication metadata

Author(s): Bell R, Pandanaboyana S, Shah N, Bartlett A, Windsor JA, Smith AM

Publication type: Review

Publication status: Published

Journal: HPB

Year: 2015

Volume: 17

Issue: 3

Pages: 202-208

Print publication date: 01/03/2015

Acceptance date: 28/08/2014

ISSN (print): 1365-182X

ISSN (electronic): 1477-2574

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/hpb.12344

PubMed id: 25267428