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Lookup NU author(s): Professor Sanjay PandanaboyanaORCiD
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© 2014 Royal Australasian College of Surgeons.This meta-analysis was designed to systematically analyse all published studies comparing local anaesthetic infiltration with wound catheters and epidural catheters in open liver resection. Methods: A literature search was performed using the Cochrane Colorectal Cancer Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials in the Cochrane Library, MEDLINE, Embase and Science Citation Index Expanded. Randomized trials, and prospective and retrospective studies comparing wound catheters with epidural catheters were included. Statistical analysis was performed using Review Manager Version 5.2 software. The primary outcome measures were pain scores in the post-operative period operation. Secondary outcome measures were hospital stay, time to opening bowels, overall complications and analgesia-specific complications. Results: Four studies including 705 patients were included in the analysis. The pain scores were significantly lower in those patients with epidural on the first post-operative day (POD) (mean difference of -0.90 [-1.29, -0.52], Z=4.61) (P<0.00001) with comparable pain scores on PODs 2 and 3. There was no significant difference in the time to opening bowels, opioid use and hospital stay between the techniques. The post-operative complication rate was higher in the epidural group (risk ratio 1.40 [1.07, 1.83]; χ2=0.60, df=1) (P=0.44); I2=0%; Z=2.42 (P=0.02). Conclusion: Local anaesthetic infiltration via wound catheters combined with patient-controlled opiate analgesia provides comparable pain relief to epidural catheters except for the first POD. Both techniques are associated with similar hospital stay and opioid use with wound catheters associated with lower complication rate.
Author(s): Bell R, Pandanaboyana S, Prasad KR
Publication type: Review
Publication status: Published
Journal: ANZ Journal of Surgery
Year: 2015
Volume: 85
Issue: 1-2
Pages: 16-21
Online publication date: 29/05/2014
Acceptance date: 22/04/2014
ISSN (print): 1445-1433
ISSN (electronic): 1445-2197
Publisher: Blackwell Publishing
URL: https://doi.org/10.1111/ans.12683
DOI: 10.1111/ans.12683
PubMed id: 24888251
