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Vagus nerve stimulation for autoimmune rheumatic diseases

Lookup NU author(s): Professor Fai NgORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


The vagus nerve is the primary parasympathetic nerve of the autonomic nervous system, providing an extensive network of afferent and efferent parasympathetic innervation of the viscera. 1 The vagus nerve comprises a bundle of approximately 80% afferent fibres and 20% efferent fibres, which control essential visceral functions including gastrointestinal motility, secretions, and heart rate. 1 Vagus nerve activity is also a prominent component of several homeostatic axes including the cholinergic anti-inflammatory pathway, the brain–gut axis, and the hypothalamic–pituitary–adrenergic axis.

Publication metadata

Author(s): Ng WF

Publication type: Article

Publication status: Published

Journal: The Lancet Rheumatology

Year: 2020

Volume: 2

Issue: 9

Pages: e512-e513

Print publication date: 01/09/2020

Online publication date: 28/07/2020

Acceptance date: 28/07/2020

Date deposited: 06/08/2020

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: Elsevier


DOI: 10.1016/S2665-9913(20)30228-9


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