Browse by author
Lookup NU author(s): Dr Keng Wooi Ng,
Dr Wing Man Lau
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.
Author(s): M Ways TM, Ng KW, Lau WM, Khutoryanskiy VV
Publication type: Article
Publication status: Published
Online publication date: 10/08/2020
Acceptance date: 06/08/2020
Date deposited: 12/08/2020
ISSN (electronic): 1999-4923
Altmetrics provided by Altmetric