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Silica Nanoparticles in Transmucosal Drug Delivery

Lookup NU author(s): Dr Keng Wooi NgORCiD, Dr Wing Man LauORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.

Publication metadata

Author(s): M Ways TM, Ng KW, Lau WM, Khutoryanskiy VV

Publication type: Article

Publication status: Published

Journal: Pharmaceutics

Year: 2020

Volume: 12

Issue: 8

Online publication date: 10/08/2020

Acceptance date: 06/08/2020

Date deposited: 12/08/2020

ISSN (electronic): 1999-4923

Publisher: MDPI


DOI: 10.3390/pharmaceutics12080751


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