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Lookup NU author(s): Dr Massimo Younes, Dr Olivier GovaereORCiD, Dr Dina Tiniakos, Professor Alastair BurtORCiD, Marco Zaki, Professor Quentin AnsteeORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
INTRODUCTION: We investigated the longitudinal impact of antinuclear antibody (ANA) on clinical outcomes and survival in nonalcoholic fatty liver disease (NAFLD). METHODS: ANA were found in 16.9% of 923 biopsy-proven NAFLD patients, but none of them had histologic autoimmune hepatitis (AIH) or developed AIH after a mean follow-up of 106±50 months. RESULTS: Although ANA-positive cases had a higher prevalence of nonalcoholic steatohepatitis at baseline, the occurrence of liver-related events, hepatocellula carcinoma, cardiovascular events, extrahepatic malignancy, and overall survival were similar to ANA-negative. DISCUSSION: Once AIH has been ruled out, the long-term outcomes and survival are unaffected by the presence of ANA in patients with NAFLD.
Author(s): Younes R, Govaere O, Petta S, Miele L, Tiniakos D, Burt A, David E, Vecchio FM, Maggioni M, Cabibi D, Fracanzani AL, Rosso C, Blanco MJG, Armandi A, Caviglia GP, Zaki MYW, Liguori A, Francione P, Pennisi G, Grieco A, Valenti L, Anstee QM, Bugianesi E
Publication type: Article
Publication status: Published
Journal: American Journal of Gastroenterology
Year: 2020
Volume: 115
Issue: 8
Pages: 1289-1292
Print publication date: 01/08/2020
Acceptance date: 02/04/2018
Date deposited: 22/10/2020
ISSN (print): 0002-9270
ISSN (electronic): 1572-0241
Publisher: Lippincott, Williams & Wilkins
URL: https://doi.org/10.14309/ajg.0000000000000676
DOI: 10.14309/ajg.0000000000000676
PubMed id: 32453041
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