Browse by author
Lookup NU author(s): Dr Michael FirbankORCiD, Professor John O'Brien, Dr Rory Durcan, Dr Louise Allan, Sally Barker, Dr Joanna Ciafone, Dr Paul Donaghy, Dr Calum Hamilton, Dr Sarah Lawley, Dr James LloydORCiD, Dr Gemma RobertsORCiD, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020, The Author(s). Objective: To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. Methods: We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative to cerebellum was calculated, and we aimed to examine differences in relative perfusion between MCI-LB and the other groups. This included whole brain voxelwise comparisons, as well as using predefined region-of-interest ratios of medial occipital to medial temporal, and posterior cingulate to precuneus. Differences in occipital perfusion in eyes open vs eyes closed conditions were also examined. Results: Compared to controls, the MCI-LB showed reduced perfusion in the precuneus, parietal, occipital and fusiform gyrus regions. In our predefined regions, the ratio of perfusion in occipital/medial temporal was significantly lower, and the posterior cingulate/precuneus ratio was significantly higher in MCI-LB compared to controls. Overall, the occipital perfusion was greater in the eyes open vs closed condition, but this did not differ between groups. Conclusion: We found patterns of altered perfusion in MCI-LB which are similar to those seen in dementia with Lewy bodies, with reduction in posterior parietal and occipital regions, but relatively preserved posterior cingulate.
Author(s): Firbank MJ, O'Brien JT, Durcan R, Allan LM, Barker S, Ciafone J, Donaghy PC, Hamilton CA, Lawley S, Lloyd J, Roberts G, Taylor J-P, Thomas AJ
Publication type: Article
Publication status: Published
Journal: Journal of Neurology
Year: 2021
Volume: 268
Pages: 1284-1294
Print publication date: 01/04/2021
Online publication date: 21/10/2020
Acceptance date: 10/10/2020
Date deposited: 05/11/2020
ISSN (print): 0340-5354
ISSN (electronic): 1432-1459
Publisher: Springer Science and Business Media Deutschland GmbH
URL: https://doi.org/10.1007/s00415-020-10271-1
DOI: 10.1007/s00415-020-10271-1
Altmetrics provided by Altmetric
