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Mitochondrial donation - hope for families with mitochondrial DNA disease

Lookup NU author(s): Dr Julie Murphy, Emeritus Professor Doug Turnbull

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Abstract

© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology. In 2015, the UK became the first country to approve the use of mitochondrial donation. This novel in vitro fertilisation treatment was developed to prevent transmission of mitochondrial DNA (mtDNA) disease and ultimately give more reproductive choice to women at risk of having severely affected offspring. The policy change was a major advance that surmounted many scientific, legislative and clinical challenges. Further challenges have since been addressed and there is now an NHS clinical service available to families with pathogenic mtDNA mutations that provides reproductive advice and options, and a research study to look at the outcome at 18 months of children born after mitochondrial donation.

Publication metadata

Author(s): Craven L, Murphy JL, Turnbull DM

Publication type: Review

Publication status: Published

Journal: Emerging Topics in Life Sciences

Year: 2020

Volume: 4

Issue: 2

Pages: 151-154

Print publication date: 01/09/2020

Online publication date: 23/06/2020

Acceptance date: 04/06/2020

ISSN (print): 2397-8554

ISSN (electronic): 2397-8562

Publisher: Portland Press Ltd

URL: https://doi.org/10.1042/ETLS20190196

DOI: 10.1042/ETLS20190196

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