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Cell therapy during machine perfusion

Lookup NU author(s): Dr Emily Thompson, Chloe Connelly, Professor Simi Ali, Professor Neil Sheerin, Colin Wilson

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This is the authors' accepted manuscript of a review published in its final definitive form in 2021. For re-use rights please refer to the publishers terms and conditions.


Abstract

There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs. This has led to the development of normothermic machine perfusion, whereby an organ is perfused with warmed, oxygenated blood and nutrients to resume normal physiological function in an isolated ex vivo platform. With this advance in preservation comes significant opportunities to recondition, repair and regenerate organs prior to transplantation using cellular therapies. This review aims to discuss the possibilities of machine perfusion technology; highlighting the potential for organ directed reconditioning and the future avenues for investigation in this field.


Publication metadata

Author(s): Thompson ER, Connelly C, Ali S, Sheerin N, Wilson C

Publication type: Review

Publication status: Published

Journal: Transplant International

Year: 2021

Volume: 34

Issue: 1

Pages: 49-58

Print publication date: 01/01/2021

Online publication date: 31/10/2020

Acceptance date: 09/10/2020

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

URL: https://doi.org/10.1111/tri.13780

DOI: 10.1111/tri.13780


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