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Lookup NU author(s): Dr Emily ThompsonORCiD,
Professor Simi Ali,
Professor Neil SheerinORCiD,
This is the authors' accepted manuscript of a review published in its final definitive form in 2021. For re-use rights please refer to the publishers terms and conditions.
There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs. This has led to the development of normothermic machine perfusion, whereby an organ is perfused with warmed, oxygenated blood and nutrients to resume normal physiological function in an isolated ex vivo platform. With this advance in preservation comes significant opportunities to recondition, repair and regenerate organs prior to transplantation using cellular therapies. This review aims to discuss the possibilities of machine perfusion technology; highlighting the potential for organ directed reconditioning and the future avenues for investigation in this field.
Author(s): Thompson ER, Connelly C, Ali S, Sheerin N, Wilson C
Publication type: Review
Publication status: Published
Journal: Transplant International
Print publication date: 01/01/2021
Online publication date: 31/10/2020
Acceptance date: 09/10/2020
ISSN (print): 0934-0874
ISSN (electronic): 1432-2277