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Role of Pre-operative Inflammatory Markers as Predictors of Lymph Node Positivity and Disease Recurrence in Well-Differentiated Pancreatic Neuroendocrine Tumours: Pancreas2000 Research and Educational Program (Course 9)

Lookup NU author(s): Pooja Prasad, Stuart Robinson



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© Copyright © 2020 Tanno, Pea, Nykänen, Prasad, Tuncer, Marchegiani and Robinson.Pancreatic neuroendocrine tumours (PNET) is a rare disease and in the absence of metastases, surgical resection is recommended. Key factors affecting survival in PNETs are the stage and grade of the disease, but there is increasing evidence suggesting lymph node involvement is associated with shorter disease-free and overall survival. Ability to predict the likelihood of lymph node involvement at the time of diagnosis would affect surgical decision making in these patients. A systemic inflammatory index such as neutrophil to lymphocyte ratio or platelet to lymphocyte ratio has been associated with poor prognosis in several cancers. Method: This study is a retrospective multi-centre study. The data including pre-operative inflammatory markers such as haemoglobin, neutrophil, lymphocyte counts and pathological data including number of positive lymph nodes, tumour grade and size, are collected to assess the association between inflammatory index and lymph node involvement. Conclusion: This study aims to assess the value of routinely available pre-operative haematological markers in predicting lymph node involvement in non-functioning PNETs.

Publication metadata

Author(s): Tanno L, Pea A, Nykanen T, Prasad P, Tuncer C, Marchegiani G, Robinson S

Publication type: Article

Publication status: Published

Journal: Frontiers in Medicine

Year: 2020

Volume: 7

Print publication date: 01/08/2020

Online publication date: 11/08/2020

Acceptance date: 10/06/2020

Date deposited: 03/12/2020

ISSN (electronic): 2296-858X

Publisher: Frontiers Research Foundation


DOI: 10.3389/fmed.2020.00346


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