Toggle Main Menu Toggle Search

Open Access padlockePrints

The Cortical Basal ganglia Functional Scale (CBFS): Development and preliminary validation

Lookup NU author(s): Dr Uma Nath, Professor Nicola PaveseORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2020 Elsevier LtdObjective: To develop a patient/care-giver reported scale capable of easily and reliably assessing functional disability in 4 repeat tauopathies (4RTs). Background: 4R tauopathies including progressive supranuclear palsy, corticobasal degeneration and a subset of frontotemporal dementias manifest a range of overlapping clinical phenotypes. No available rating scale is capable of evaluating the functional impact of these complex disorders. Methods: A multi-staged modified Delphi process was used to propose, evaluate and rank potential scale items providing content validity ratios. Staged cognitive pretesting involving input from examiners, patients and caregivers was followed by validation testing in patients participating in the 4R Tauopathy Neuroimaging Initiative or the PROgressive Supranuclear Palsy CorTico-Basal Syndrome MSA Longitudinal Study. Clinimetric properties were examined using classical test theory and item response methods, assessing data quality, reliability, construct validity, convergent validity and known-group validity. Results: The resultant Cortical Basal ganglia Functional Scale (CBFS) included questions on Motor Experiences in Daily Living (14 items) and Non-Motor Experiences of Daily Living (17 items). Reliability was acceptable for internal consistency, test-retest stability, item discrimination, item-scaling thresholds and item-fit. Examination of construct validity revealed a parsimonious two-factor solution, and concurrent validity demonstrated significant correlations between the CBFS and other measures of disease severity and functional impairment. The CBFS significantly discriminated between all diagnostic groups and controls (all AUCs>90). The CBFS scores demonstrated sensitivity to change over a 12 month follow-up in patients with probable 4RTs. Conclusions: The CBFS is a patient/care-giver reported outcome measure with excellent clinimetric properties that captures disability correlated with motor, cognitive and psychiatric impairments.

Publication metadata

Author(s): Lang AE, Stebbins GT, Wang P, Jabbari E, Lamb R, Morris H, Boxer AL, Boxer (PI) A, Boeve B, Dickerson B, Grossman M, Litvan I, Ljubenkov P, Pantelyat A, Rojas-Martinez J, Tartaglia M-C, Wills A-M, Morris (PI) H, Amar K, Capps E, Carey G, Church A, Critchley P, Ghosh B, Houlden H, Hu M, Kobylecki C, Massey L, Molloy S, Nath U, Pavese N, Rowe JB

Publication type: Article

Publication status: Published

Journal: Parkinsonism and Related Disorders

Year: 2020

Volume: 79

Pages: 121-126

Print publication date: 01/10/2020

Online publication date: 24/08/2020

Acceptance date: 15/08/2020

ISSN (print): 1353-8020

ISSN (electronic): 1873-5126

Publisher: Elsevier Ltd


DOI: 10.1016/j.parkreldis.2020.08.021

PubMed id: 32947108


Altmetrics provided by Altmetric