Toggle Main Menu Toggle Search

Open Access padlockePrints

Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database

Lookup NU author(s): Dr Mohaned Egred


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2020 Wiley Periodicals LLCIntroduction: Excimer laser coronary atherectomy (ELCA) is a recognized adjunctive therapy utilized in the percutaneous management of complex coronary lesions. Studies examining its safety and utility have been limited by small sample sizes. Our study examines the determinants and outcomes of ELCA. Methods: Using the British Cardiac Intervention Society database, data were analyzed on all PCI procedures in the UK between 2006–2016. Descriptive statistics and multivariate logistic regressions were used to examine baseline, procedural and outcome associations with ELCA. Results: We identified 1,471 (0.21%) ELCA cases out of 686,358 PCI procedures. Baseline covariates associated with ELCA use were age, BMI, number of lesions, CTO or restenosis attempted and history of prior MI, CABG or PCI. Procedural co-variates associated with ELCA were the use of glycoprotein inhibitors, intravascular imaging, rotational atherectomy, cutting balloons, microcatheters and intra-aortic balloon pumps. Adjusted rates of in-hospital major adverse cardiac/cerebrovascular events (MACCE) or its individual components (death, peri-procedural MI, stroke and major bleed) were not significantly altered by the use of ELCA. However, there were higher odds of dissection (OR 1.52, 95% CI 1.17–1.98), perforation (OR 2.18, 95% CI 1.44–3.30), slow flow (OR: 1.67, 95% CI 1.18–2.36), reintervention (OR: 2.12, 95% CI 1.14–3.93) and arterial complications (OR: 1.63, 95% CI 1.21–2.21). Conclusions: ELCA use during complex PCI is associated with higher risk baseline and procedural characteristics. Although increased rates of acute procedural complications were observed, ELCA does not increase likelihood of in-hospital MACCE or its individual components.

Publication metadata

Author(s): Protty MB, Hussain HI, Gallagher S, Al-Raisi S, Aldalati O, Farooq V, Sharp ASP, Egred M, O'Kane P, Ludman P, Anderson RA, Mamas MA, Kinnaird T

Publication type: Article

Publication status: Published

Journal: Catheterization and Cardiovascular Interventions

Year: 2020

Pages: epub ahead of print

Online publication date: 18/09/2020

Acceptance date: 02/08/2020

ISSN (print): 1522-1946

ISSN (electronic): 1522-726X

Publisher: John Wiley and Sons Inc


DOI: 10.1002/ccd.29251


Altmetrics provided by Altmetric


Find at Newcastle University icon    Link to this publication