Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity

Lookup NU author(s): Professor Christopher DuncanORCiD, Professor Sophie HambletonORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© 2020 The AuthorsThe concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa-restricted type III IFNs (IFN-III), informing our understanding of the place of the IFN system within the concerted antiviral response. Here we review monogenic lesions of IFN-I signalling pathways and summarise the organising principles which emerge.

Publication metadata

Author(s): Duncan CJA, Randall RE, Hambleton S

Publication type: Review

Publication status: Published

Journal: Trends in Genetics

Year: 2021

Volume: 37

Issue: 1

Pages: 46-58

Print publication date: 01/01/2021

Online publication date: 22/09/2020

Acceptance date: 20/08/2020

ISSN (print): 0168-9525

ISSN (electronic): 1362-4555

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.tig.2020.08.017

DOI: 10.1016/j.tig.2020.08.017

Share