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Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity

Lookup NU author(s): Dr Christopher DuncanORCiD, Professor Sophie HambletonORCiD


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© 2020 The AuthorsThe concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa-restricted type III IFNs (IFN-III), informing our understanding of the place of the IFN system within the concerted antiviral response. Here we review monogenic lesions of IFN-I signalling pathways and summarise the organising principles which emerge.

Publication metadata

Author(s): Duncan CJA, Randall RE, Hambleton S

Publication type: Review

Publication status: Published

Journal: Trends in Genetics

Year: 2021

Volume: 37

Issue: 1

Pages: 46-58

Print publication date: 01/01/2021

Online publication date: 22/09/2020

Acceptance date: 20/08/2020

ISSN (print): 0168-9525

ISSN (electronic): 1362-4555

Publisher: Elsevier Ltd


DOI: 10.1016/j.tig.2020.08.017