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Transient loss of endothelial cells in human spiral artery remodelling during early pregnancy: Challenging the dogma

Lookup NU author(s): Dr Judith Bulmer, Barbara Innes, Professor Steve RobsonORCiD, Dr Gendie Lash


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© 2020 Elsevier LtdSpiral artery (SpA) remodelling is essential for a successful pregnancy and is best described by its morphological features; vascular smooth muscle cell separation and loss, vessel dilatation, and invasion by extravillous trophoblast cells (EVT). Current opinion holds that EVT fully replace the endothelial cells (EC) of the SpA and take on EC-like characteristics. Placental bed biopsies (6–20 weeks gestation) were immunostained for EC and EVT, showing transient loss of EC. In vessels containing an endovascular EVT plug (n = 28) 77.6 ± 19.3% of the lumen was covered by EC while in vessels without endovascular EVT (n = 100) it was 100 ± 0%.

Publication metadata

Author(s): Bulmer JN, Innes BA, Robson SC, Lash GE

Publication type: Article

Publication status: Published

Journal: Placenta

Year: 2020

Volume: 101

Pages: 230-233

Print publication date: 02/11/2020

Online publication date: 01/10/2020

Acceptance date: 01/10/2020

ISSN (print): 0143-4004

ISSN (electronic): 1532-3102

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.placenta.2020.10.003

PubMed id: 33027741


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