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A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type

Lookup NU author(s): Emeritus Professor Robert Perry


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In a previous study we reported no difference in the overall beta-amyloid protein (beta AP) load between Alzheimer's disease (AD) and senile dementia of the Lewy body type (SDLT). However, it is possible that differences in the morphology of beta AP plaque types exist, analogous to the differences in cytoskeletal pathology found in these two disorders. We have carried out a quantitative image analysis of plaque subtypes in the temporal lobe of AD (n = 8), SDLT (ii = 9) and control (n = 11) cases. Measurements of beta AP load and plaque density were consistently higher in AD and SDLT than in controls. When AD and SDLT cases were compared no differences were seen in either the density or relative proportions of classic and diffuse plaques. Based on these results we suggest that the variation in the clinical course of these diseases reflects differences in the cytoskeletal pathology, whereas the final state of profound dementia common to both disorders is associated with the deposition of beta AP.

Publication metadata

Author(s): McKenzie JE, Edwards RJ, Gentleman SM, Ince PG, Perry RH, Royston MC, Roberts GW

Publication type: Article

Publication status: Published

Journal: Acta Neuropathologica

Year: 1996

Volume: 91

Issue: 5

Pages: 526-529

Print publication date: 01/04/1996

ISSN (print): 0001-6322

ISSN (electronic): 1432-0533

Publisher: Springer


DOI: 10.1007/s004010050461


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