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Detection of an unusual G8P[8] rotavirus in a Rotarix-vaccinated child with acute gastroenteritis using Nanopore MinION sequencing: A case report

Lookup NU author(s): Emeritus Professor Alan Ward

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Abstract

ys with severe gastroenteritis, including high fever, vomiting, diarrhea, mild dehydration, and periumbilical pain. Notably, the patient previously received the Rotarix vaccine. DIAGNOSES: The laboratory tests were negative for rotavirus, astrovirus, adenovirus, and norovirus as well as common diarrhea-causing bacteria. Human-bovine recombinant rotavirus was detected by MinION sequencing. INTERVENTIONS: To investigate the cause agents from the unexplained severe gastroenteritis infant, the stool sample was prepared by random amplification for Nanopore MinION sequencing. OUTCOMES: Treatment through the administration of ORS solution and galtase powder with probiotics was successful after the diagnosis of unusual rotavirus infection. LESSONS: This case report is the first detection of an unusual human-bovine recombinant rotavirus in an idiopathic gastroenteritis using Nanopore MinION sequencing.

Publication metadata

Author(s): Kim J-H, Yi DY, Lim I, Ward AC, Kim W

Publication type: Article

Publication status: Published

Journal: Medicine

Year: 2020

Volume: 99

Issue: 40

Online publication date: 02/10/2020

Acceptance date: 09/09/2020

ISSN (print): 0025-7974

ISSN (electronic): 1536-5964

Publisher: Wolters Kluwer Health

URL: https://doi.org/10.1097/MD.0000000000022641

DOI: 10.1097/MD.0000000000022641

PubMed id: 33019489

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