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Nonantibiotic treatments for urinary cystitis: an update

Lookup NU author(s): Professor Christopher HardingORCiD


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PURPOSE OF REVIEW: Urinary tract infections (UTIs) are one of most common infections in everyday clinical practice. Given the increase in antimicrobial therapy resistance, there has been an increased interest in nonantibiotic treatment options for common infections. RECENT FINDINGS: A review of the recent literature including on nonantibiotic options for management of UTIs, symptoms of cystitis and prevention of recurrent UTIs. SUMMARY: The article provides an overview on alternative therapy to antibiotics in the treatment of cystitis and recurrent UTI prophylaxis, including alkalinization of urine, cranberry products, probiotics, NSAIDS, D-mannose, herbal medicine, methenamine hippurate, oral immunostimulants (immunotherapy), topical oestrogens, vitamins and acupuncture. The last few years of intense research has focused on an effort to find evidence to corroborate potentially efficacious non antibiotic treatments. However, alternative treatments for UTIs have not brought conclusive evidence that antibiotic usage can be replaced completely by nonantibiotic options. The reason for this is largely due to a lack of good-quality randomized controlled trials on this subject.

Publication metadata

Author(s): Barea BM, Veeratterapillay R, Harding C

Publication type: Article

Publication status: Published

Journal: Current opinion in urology

Year: 2020

Volume: 30

Issue: 6

Pages: 845-852

Online publication date: 01/11/2020

Acceptance date: 02/04/2016

ISSN (print): 0963-0643

ISSN (electronic): 1473-6586

Publisher: Lippincott, Williams & Wilkins


DOI: 10.1097/MOU.0000000000000821

PubMed id: 33009152


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