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Primary pneumococcal peritonitis can be the first presentation of a familial complement factor I deficiency

Lookup NU author(s): Dr Sanj Ugrinovic, Professor David KavanaghORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Primary pneumococcal peritonitis is a rare infection that has been described in women but has not been previously linked with immunodeficiency. The complement system plays a central role in immune defence against Streptococcus pneumoniae and, in order to evade complement attack, pneumococci have evolved a large number of mechanisms that limit complement-mediated opsonization and subsequent phagocytosis. We investigated an apparently immunocompetent woman with primary pneumococcal peritonitis and identified a family with deficiency for complement factor I. Primary pneumococcal peritonitis should be considered a possible primary immunodeficiency presentation.

Publication metadata

Author(s): Ugrinovic S, Firth H, Kavanagh D, Gouliouris T, Gurugama P, Baxendale H, Lachmann PJ, Kumararatne D, Gkrania-Klotsas E

Publication type: Article

Publication status: Published

Journal: Clinical & Experimental Immunology

Year: 2020

Volume: 202

Issue: 3

Pages: 379-383

Print publication date: 01/12/2020

Online publication date: 08/07/2020

Acceptance date: 22/06/2020

Date deposited: 25/11/2020

ISSN (print): 0009-9104

ISSN (electronic): 1365-2249

Publisher: Wiley


DOI: 10.1111/cei.13490

PubMed id: 32640035


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