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New concepts in the development and malformation of the arterial valves

Lookup NU author(s): Professor Deborah HendersonORCiD, Dr Lorraine Eley, Dr Bill Chaudhry



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020, MDPI AG. All rights reserved.Although in many ways the arterial and atrioventricular valves are similar, both being derived for the most part from endocardial cushions, we now know that the arterial valves and their surrounding structures are uniquely dependent on progenitors from both the second heart field (SHF) and neural crest cells (NCC). Here, we will review aspects of arterial valve development, highlighting how our appreciation of NCC and the discovery of the SHF have altered our developmental models. We will highlight areas of research that have been particularly instructive for understanding how the leaflets form and remodel, as well as those with limited or conflicting results. With this background, we will explore how this developmental knowledge can help us to understand human valve malformations, particularly those of the bicuspid aortic valve (BAV). Controversies and the current state of valve genomics will be indicated.

Publication metadata

Author(s): Henderson DJ, Eley L, Chaudhry B

Publication type: Review

Publication status: Published

Journal: Journal of Cardiovascular Development and Disease

Year: 2020

Volume: 7

Issue: 4

Pages: 1-27

Online publication date: 24/09/2020

Acceptance date: 23/09/2020

ISSN (electronic): 2308-3425

Publisher: MDPI AG


DOI: 10.3390/jcdd7040038