Cyclic Peptides as Chemical Probes

Serrano, L; Roper, G; Kawamura, A

doi:10.1039/9781839160745

Cyclic Peptides as Chemical Probes

Lookup NU author(s): Professor Akane Kawamura

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This is the authors' accepted manuscript of a book chapter that has been published in its final definitive form by Royal Society of Chemistry, 2020.

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Abstract

Cyclic peptides are an exciting class of compounds that are currently under-exploited as chemical probes. Recent advances in peptide chemistry, screening and sequencing technologies have enabled efficient generation and screening of natural-product like cyclic peptide libraries to identify high-affinity and -selectivity ligands against targets of interest, providing new opportunities for chemical probes development, including for challenging targets. In this chapter, we review the recent advances in the cyclic peptide technologies and provide examples where cyclic peptides have been used to study the biology of their targets.