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Lookup NU author(s): Professor Akane Kawamura
This is the authors' accepted manuscript of a book chapter that has been published in its final definitive form by Royal Society of Chemistry, 2020.
For re-use rights please refer to the publisher's terms and conditions.
Cyclic peptides are an exciting class of compounds that are currently under-exploited as chemical probes. Recent advances in peptide chemistry, screening and sequencing technologies have enabled efficient generation and screening of natural-product like cyclic peptide libraries to identify high-affinity and -selectivity ligands against targets of interest, providing new opportunities for chemical probes development, including for challenging targets. In this chapter, we review the recent advances in the cyclic peptide technologies and provide examples where cyclic peptides have been used to study the biology of their targets.
Author(s): Serrano L, Roper G, Kawamura A
Editor(s): Paul Brennan, Saleta Vazquez Rodriguez
Publication type: Book Chapter
Publication status: Published
Book Title: The Discovery and Utility of Chemical Probes in Target Discovery
Print publication date: 26/11/2020
Acceptance date: 23/05/2020
Publisher: Royal Society of Chemistry
Place Published: Cambridge
Library holdings: Search Newcastle University Library for this item