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Drug biotransformation process favored by fungal biofilms formed on a proposed fixed bed-airlift hybrid reactor

Lookup NU author(s): Professor Jarka Glassey

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Abstract

© 2020 Society of Chemical Industry (SCI). BACKGROUND: Fungi have the great ability to biotransform drugs, making it possible to direct their application to obtaining new molecules. Our group developed a hybrid fixed bed-airlift reactor (FB-ALR) model that allows the formation of Cunninghamella elegans (or other fungi) biofilm and biotransformation of diclofenac (DCF). RESULTS: Hydrodynamic and rheological parameters [(mixing time (tM), linear gas velocity (UG), liquid linear velocity (UL), gas hold-up (εG), viscosity (v)], mass transfer (kLa) and biomass formation were superior than those obtained in conventional airlift reactor (ALR) and bubble column reactor. The higher performance of FB-ALR is a result of the improvement in the oxygenation process, in addition to the reticulate baffle used by the fungus as a support for adhesion and proliferation as biofilm. The formation of fungal biofilms, in addition to reducing the viscosity of the system, favored the retention of DCF, thus facilitating the processes of biotransformation. High-performance liquid chromatography analyses confirmed such theory. CONCLUSION: Fungal biofilms present considerable biotransforming activity, making FB-ALR the highest yielding biotransformation system amongst those tested herein. © 2020 Society of Chemical Industry (SCI).

Publication metadata

Author(s): Bianchini LF, da Silva Ramos RCP, de Oliveira NS, de Paula RC, Rosa RT, Glassey J, Rosa EAR

Publication type: Article

Publication status: Published

Journal: Journal of Chemical Technology and Biotechnology

Year: 2021

Volume: 96

Issue: 4

Pages: 999-1006

Print publication date: 01/04/2021

Online publication date: 12/11/2020

Acceptance date: 12/11/2020

ISSN (print): 0268-2575

ISSN (electronic): 1097-4660

Publisher: John Wiley and Sons Ltd

URL: https://doi.org/10.1002/jctb.6610

DOI: 10.1002/jctb.6610

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