Browse by author
Lookup NU author(s): Jordan Marley
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2020 UICC. One of the most common promoters of the initiation and growth of the tumor is an immune disturbance. Numerous immune cells and inflammatory factors play a role in the tumor-immune microenvironment. However, few studies have investigated the correlation between these immunological events and clinical consequences in cervical cancer. We measured the levels of numerous inflammatory mediators and frequencies of regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and mucosal-associated invariant T (MAIT) cells in peripheral blood (PB) of cervical cancer patients. Cervical cancer patients showed elevated production of interleukin (IL)-18 and plasma C-C chemokine ligand (CCL) 3/5. Meanwhile, an accumulation of C-C chemokine receptor 5 (CCR5) monocytic (Mo)-MDSCs and Tregs was observed. The cervical cancer group displayed increased frequencies of CD8+, CD4+ and highly activated CD38+CD8+MAIT cells, and reduction of double-negative (DN) and PD1(CD279+) DN MAIT cells. Importantly, it was demonstrated that MAIT cells were positively related to Mo-MDSCs. Furthermore, an elevated concentration of PD1(CD279+) DN MAIT cells was significantly related to increased progression-free survival of patients with cervical cancer. In conclusion, our study suggests that the combined action of Mo-MDSCs and MAIT cells might be associated with the progression of cervical cancer, and the frequency of DN MAIT cells in the peripheral blood mononuclear cells was associated with the survival benefit of patients.
Author(s): Lu Z, Zhu M, Marley JL, Bi K, Wang K, Zhai M, Hu H, Guo P, Li C, Xu Y, Chen Y, Zhou P, Wei Z, Jiang H, Cao Y
Publication type: Article
Publication status: Published
Journal: International Journal of Cancer
Year: 2021
Volume: 148
Issue: 6
Pages: 1499-1507
Print publication date: 15/03/2021
Online publication date: 27/11/2020
Acceptance date: 13/11/2020
ISSN (print): 0020-7136
ISSN (electronic): 1097-0215
Publisher: Wiley-Liss Inc.
URL: https://doi.org/10.1002/ijc.33411
DOI: 10.1002/ijc.33411
PubMed id: 33245569
Altmetrics provided by Altmetric
