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Paediatric sudden unexpected death in epilepsy: A parental report cohort

Lookup NU author(s): Dr Rhys ThomasORCiD


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© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Background: Sudden unexpected death in epilepsy (SUDEP) accounts for a large percentage of deaths in children with epilepsy. Contributing factors to paediatric SUDEP are incompletely understood. Aims of Study: The Epilepsy Deaths Register (EDR) is an anonymized register that compiles information on deaths related to epilepsy, across all ages and epilepsy classifications. Using the EDR, we sought to identify key risk factors for SUDEP in children to assist the development of preventive measures. Methods: All registrations between the ages of 1 and 16 years were reviewed to identify definite or probable SUDEP. These cases were analysed to identify common demographics, comorbidities, monitoring, treatments and circumstances near to the deaths. Results: We identified forty-six cases (27 males) of definite or probable SUDEP. Paediatric SUDEP is more common in a 12- to 16-year age group and in those with neuro-disability. Most paediatric SUDEP occurs during apparent sleep. There were four cases with a vagus nerve stimulator. SUDEP can occur early after the onset of seizures. Conclusions: This is the largest single cohort of SUDEP reported in children. Reports from caregivers can augment population data. Surveillance in sleep is a priority area of development.

Publication metadata

Author(s): Craig DP, Choi YY, Hughes E, Osland K, Hanna J, Kerr MP, Thomas RH

Publication type: Article

Publication status: Published

Journal: Acta Neurologica Scandinavica

Year: 2021

Volume: 143

Issue: 5

Pages: 509-513

Print publication date: 01/05/2021

Online publication date: 19/11/2020

Acceptance date: 12/11/2020

ISSN (print): 0001-6314

ISSN (electronic): 1600-0404

Publisher: John Wiley & Sons Ltd


DOI: 10.1111/ane.13378

PubMed id: 33210735


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