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Relationship between urinary nitrate concentrations and cognitive function in older adults: findings from the NHANES survey

Lookup NU author(s): Dr Oliver Shannon, Abrar Babateen, Ammar Ashor, Professor Bloss Stephan, Dr Mario Siervo


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© 2021 Taylor & Francis Group, LLC. This study evaluated the association of urinary nitrate concentrations with cognition in older subjects enrolled in the NHANES study. We also explored whether associations between urinary nitrate and cognition were modified by cardiovascular risk, vitamin D status and vitamin C intake. Two NHANES cycles were merged (2011–2012 and 2013–2014) and a total of 1,015 adults aged 60–80 (69.4 ± 0.3) years were included. Cognition was assessed using the Word List Learning, Word List Recall, Animal Fluency and the Digit Symbol Substitution tests. Urinary nitrate was analysed using electrospray tandem mass spectrometry. Urinary nitrate concentrations were not associated with cognitive performance on any of the cognitive tests. Associations were also not significant in subjects at greater risk for cognitive impairment (i.e. high cardiovascular risk and non-optimal vitamin D status). Longitudinal analyses are needed to explore the associations of urinary nitrate concentrations with dietary nitrate intake and cognitive function.

Publication metadata

Author(s): Pereira LCR, Shannon OM, Mazidi M, Babateen AM, Ashor AW, Stephan BCM, Siervo M

Publication type: Article

Publication status: Published

Journal: International Journal of Food Sciences and Nutrition

Year: 2021

Volume: 72

Issue: 6

Pages: 805-815

Online publication date: 04/01/2021

Acceptance date: 20/12/2020

ISSN (print): 0963-7486

ISSN (electronic): 1465-3478

Publisher: Taylor and Francis Ltd


DOI: 10.1080/09637486.2020.1868411


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