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An increase in fat-free mass is associated with higher appetite and energy intake in older adults: A randomised control trial

Lookup NU author(s): Dr Adrian Holliday

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Abstract

© 2021 by the authors. Li-censee MDPI, Basel, Switzerland.Cross-sectional studies in younger adults have demonstrated a positive association between energy intake (EI) and fat-free mass (FFM), with this relationship seemingly mediated by resting metabolic rate (RMR). Establishing a causal effect longitudinally would be prudent in older adults suffering from loss of appetite. We investigated the effects of FFM on RMR, appetite and EI in 39 healthy older adults (age: 66 ± 4 years, BMI: 25.1 ± 3.5 kg·m2 ) assigned to either 12-week resistance training + protein supplementation group (RT + PRO) or control group (CON). Body composition, subjective appetite, leptin, insulin, RMR and laboratory-measured ad libitum EI were measured at baseline, weeks 6 and 12 of the intervention, while daily EI at baseline and week 12. FFM (+1.2 kg; p = 0.002), postprandial subjective appetite (+8 mm; p = 0.027), ad libitum EI (+119 kcal; p = 0.012) and daily EI (+133 kcal; p = 0.010) increased from baseline to week 12 in the RT + PRO. RMR, fasted subjective appetite, leptin and insulin concentrations remained unchanged (all p > 0.05). The increases ad libitum EI correlated with increases in FFM (r = 0.527, p = 0.001), with 54% of the change in EI attributed to FFM changes. In conclusion, FFM increases were associated with an increased ad libitum EI and postprandial appetite in older adults.

Publication metadata

Author(s): Johnson KO, Holliday A, Mistry N, Cunniffe A, Howard K, Stanger N, O'mahoney LL, Matu J, Ispoglou T

Publication type: Article

Publication status: Published

Journal: Nutrients

Year: 2021

Volume: 13

Issue: 1

Online publication date: 01/01/2021

Acceptance date: 15/12/2020

Date deposited: 19/07/2022

ISSN (electronic): 2072-6643

Publisher: MDPI AG

URL: https://doi.org/10.3390/nu13010141

DOI: 10.3390/nu13010141

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