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Fut8 alpha-(1,6)-fucosyltransferase in cancer

Lookup NU author(s): Kayla Bastian, Dr Emma ScottORCiD, Professor David Elliott, Dr Jennifer Munkley

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the innermost GlcNAc residue of N-glycans. FUT8 is frequently upregulated in cancer, and plays a critical role in immune evasion, antibody-dependent cellular cytotoxicity (ADCC), and the regulation of TGF-β, EGF, α3β1 integrin and E-Cadherin. Here, we summarise the role of FUT8 in various cancers (including lung, liver, colorectal, ovarian, prostate, breast, melanoma, thyroid, and pancreatic), discuss the potential mechanisms involved, and outline opportunities to exploit FUT8 as a critical factor in cancer therapeutics in the future.

Publication metadata

Author(s): Bastian K, Scott E, Elliott DJ, Munkley J

Publication type: Review

Publication status: Published

Journal: International Journal of Molecular Sciences

Year: 2021

Volume: 22

Issue: 1

Pages: 1-22

Online publication date: 05/01/2021

Acceptance date: 24/12/2020

ISSN (print): 1661-6596

ISSN (electronic): 1422-0067

Publisher: MDPI AG

URL: https://doi.org/10.3390/ijms22010455

DOI: 10.3390/ijms22010455

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