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Lookup NU author(s): James Hunter,
Professor Mike Waring
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DNA-encoded combinatorial libraries (DECLs) represent an exciting new technology for high-throughput screening, significantly increasing its capacity and cost-effectiveness. Historically, DECLs have been the domain of specialized academic groups and industry; however, there has recently been a shift toward more drug discovery academic centers and institutes adopting this technology. Key to this development has been the simplification, characterization and standardization of various DECL subprotocols, such as library design, affinity screening and data analysis of hits. This review examines the feasibility of implementing DECL screening technology as a first-time user, particularly in academia, exploring the some important considerations for this, and outlines some applications of the technology that academia could contribute to the field.
Author(s): Conole D, Hunter JH, Waring MJ
Publication type: Article
Publication status: Published
Journal: Future Medicinal Chemistry
Online publication date: 04/12/2020
Acceptance date: 11/12/2020
ISSN (print): 1756-8919
ISSN (electronic): 1756-8927
Publisher: Newlands Press
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