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Surgical Advances in Osteosarcoma

Lookup NU author(s): Marcus BrookesORCiD, Dr Corey ChanORCiD, Zakareya Gamie, Tom Beckingsale, Katarina Ghosh, Dr Kenneth RankinORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Osteosarcoma (OS) is the most common primary bone cancer in children and, unfortunately, is associated with poor survival rates. OS most commonly arises around the knee joint, and was traditionally treated with amputation until surgeons began to favour limb‐preserving surgery in the 1990s. Whilst improving functional outcomes, this was not without problems, such as implant failure and limb length discrepancies. OS can also arise in areas such as the pelvis, spine, head, and neck, which creates additional technical difficulty given the anatomical complexity of the areas. We reviewed the literature and summarised the recent advances in OS surgery. Improvements have been made in many areas; developments in pre‐operative imaging technology have allowed improved planning, whilst the ongoing development of intraoperative imaging techniques, such as fluorescent dyes, offer the possibility of improved surgical margins. Technological developments, such as computer navigation, patient specific instruments, and improved implant design similarly provide the opportunity to improve patient outcomes. Going forward, there are a number of promising avenues currently being pursued, such as targeted fluorescent dyes, robotics, and augmented reality, which bring the prospect of improving these outcomes further.

Publication metadata

Author(s): Brookes MJ, Chan CD, Baljer B, Wimalagunaratna S, Crowley TP, Ragbir M, Irwin A, Gamie Z, Beckingsale T, Ghosh KM, Rankin KS

Publication type: Review

Publication status: Published

Journal: Cancers

Year: 2021

Volume: 13

Issue: 3

Online publication date: 21/01/2021

Acceptance date: 18/01/2021

ISSN (electronic): 2072-6694

Publisher: MDPI AG


DOI: 10.3390/cancers13030388