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Measurement of intraorgan fat and hepatic output of triglycerides in human type 2 diabetes by magnetic resonance and Intralipid infusion techniques

Lookup NU author(s): Dr Ahmad Al-Mrabeh, Dr Carl Peters, Dr Kieren Hollingsworth, Professor Roy Taylor

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Abstract

Liver fat content and the linked rate of export of triglyceride are central to aetiology of type 2 diabetes, as well as to the cardiovascular effects of fatty liver disease. Measurement in human of intrahepatic and intrapancreatic fat content is described using magnetic resonance techniques and quantification of the rate of hepatic secretion of very low-density lipoprotein using a non-isotopic competitive blocking of tissue uptake. This protocol is non-invasive, able to be repeated sequentially and does not involve ionizing radiation.

Publication metadata

Author(s): Al-Mrabeh A, Peters C, Hollingsworth KG, Taylor R

Publication type: Article

Publication status: Published

Journal: STAR Protocols

Year: 2021

Volume: 2

Issue: 1

Print publication date: 19/03/2021

Online publication date: 02/03/2021

Acceptance date: 27/01/2021

Date deposited: 04/05/2021

ISSN (electronic): 2666-1667

Publisher: Cell Press

URL: https://doi.org/10.1016/j.xpro.2021.100355

DOI: 10.1016/j.xpro.2021.100355

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