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The effect of acute and repeated ischemic preconditioning on recovery following exercise-induced muscle damage

Lookup NU author(s): Simon Patterson, Dr Owen JeffriesORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Objectives: The aim of this investigation was to determine if acute or repeated applications of ischemic preconditioning (IPC) could enhance the recovery process, following exercise induced muscle damage (EIMD). Design: Randomized control trial. Methods: Twenty-three healthy males were familiarised with the muscle damaging protocol (five sets of 20 drop jumps from a 0.6 m box) and randomly allocated to one of three groups: SHAM (3 x 5 min at 20 mmHg), Acute IPC (3 x 5 min at 220 mmHg) and Repeated IPC (3 days x 3 x 5 min at 220 mmHg). The indices of muscle damage measured included creatine kinase concentration ([CK]), thigh swelling, delayed onset muscle soreness, counter movement jumps (CMJ) and maximal voluntary isometric contraction (MVIC). Results: Both acute and repeated IPC improved recovery in MVIC versus SHAM. Repeated IPC led to a faster MVIC recovery at 48 h (101.5%) relative to acute IPC (92.6%) and SHAM (84.4%) (P < 0.05). Less swelling was found for both acute and repeated IPC vs. SHAM (P < 0.05) but no group effects were found for CMJ, soreness or [CK] responses (P > 0.05). Conclusion: Taken together, repeated IPC can enhance recovery time of MVIC more than an acute application, and both reduce swelling following EIMD, relative to a SHAM condition.

Publication metadata

Author(s): Patterson SD, Swan R, Page W, Marocolo M, Jeffries O, Waldron M

Publication type: Article

Publication status: Published

Journal: Journal of Science and Medicine in Sport

Year: 2021

Volume: 24

Issue: 7

Pages: 709-714

Print publication date: 01/07/2021

Online publication date: 23/02/2021

Acceptance date: 15/02/2021

Date deposited: 18/02/2021

ISSN (print): 1440-2440

ISSN (electronic): 1878-1861

Publisher: Elsevier Australia


DOI: 10.1016/j.jsams.2021.02.012


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