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There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia

Lookup NU author(s): Dr Clive Kelly


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© 2021, Royal Academy of Medicine in Ireland.Introduction: There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. Methods: This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders. Results: The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this. Discussion: We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other.

Publication metadata

Author(s): Williamson J, Black L, Black A, Koduri G, Kelly C

Publication type: Review

Publication status: Published

Journal: Irish Journal of Medical Science

Year: 2022

Volume: 191

Pages: 1-5

Print publication date: 01/02/2022

Online publication date: 10/02/2021

Acceptance date: 02/02/2021

ISSN (print): 0021-1265

ISSN (electronic): 1863-4362

Publisher: Springer Science and Business Media Deutschland GmbH


DOI: 10.1007/s11845-021-02545-y