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Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)

Lookup NU author(s): Henri Bertrand, Professor Stuart BakerORCiD, Emeritus Professor Paul FlecknellORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© The Author(s) 2021.This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.

Publication metadata

Author(s): Bertrand HGMJ, Middleton JA, Baker SN, Glover I, Flecknell PA

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 2021

Pages: epub ahead of print

Online publication date: 09/02/2021

Acceptance date: 21/12/2020

Date deposited: 18/01/2021

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: SAGE Publications Ltd


DOI: 10.1177/0023677221990706


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