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Lookup NU author(s): Professor Simon PearceORCiD, Dr Earn Gan, Dr Catherine Napier
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 The authors Published by Bioscientifica Ltd. Printed in Great BritainOver the last 10 years, evidence has accumulated that autoimmune Addison's disease (AAD) is a heterogeneous disease. Residual adrenal function, characterised by persistent secretion of cortisol, other glucocorticoids and mineralocorticoids is present in around 30% of patients with established AAD, and appears commoner in men. This persistent steroidogenesis is present in some patients with AAD for more than 20 years, but it is commoner in people with shorter disease duration. The clinical significance of residual adrenal function is not fully clear at the moment, but as it signifies an intact adrenocortical stem cell population, it opens up the possibility of regeneration of adrenal steroidogenesis and improvement in adrenal failure for some patients.
Author(s): Pearce SHS, Gan EH, Napier C
Publication type: Review
Publication status: Published
Journal: European Journal of Endocrinology
Year: 2021
Volume: 184
Issue: 2
Pages: R61-R67
Online publication date: 01/02/2021
Acceptance date: 08/12/2020
ISSN (print): 0804-4643
ISSN (electronic): 1479-683X
Publisher: BioScientifica Ltd.
URL: https://doi.org/10.1530/EJE-20-0894
DOI: 10.1530/EJE-20-0894
PubMed id: 33306039
