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Residual adrenal function in Addison's disease

Lookup NU author(s): Professor Simon PearceORCiD, Dr Earn Gan, Dr Catherine Napier



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021 The authors Published by Bioscientifica Ltd. Printed in Great BritainOver the last 10 years, evidence has accumulated that autoimmune Addison's disease (AAD) is a heterogeneous disease. Residual adrenal function, characterised by persistent secretion of cortisol, other glucocorticoids and mineralocorticoids is present in around 30% of patients with established AAD, and appears commoner in men. This persistent steroidogenesis is present in some patients with AAD for more than 20 years, but it is commoner in people with shorter disease duration. The clinical significance of residual adrenal function is not fully clear at the moment, but as it signifies an intact adrenocortical stem cell population, it opens up the possibility of regeneration of adrenal steroidogenesis and improvement in adrenal failure for some patients.

Publication metadata

Author(s): Pearce SHS, Gan EH, Napier C

Publication type: Review

Publication status: Published

Journal: European Journal of Endocrinology

Year: 2021

Volume: 184

Issue: 2

Pages: R61-R67

Online publication date: 01/02/2021

Acceptance date: 08/12/2020

ISSN (print): 0804-4643

ISSN (electronic): 1479-683X

Publisher: BioScientifica Ltd.


DOI: 10.1530/EJE-20-0894

PubMed id: 33306039