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Hippocampal and insula volume in mild cognitive impairment with Lewy bodies

Lookup NU author(s): Dr Michael FirbankORCiD, Dr Rory Durcan, Professor John O'Brien, Dr Louise Allan, Sally Barker, Dr Joanna Ciafone, Dr Paul DonaghyORCiD, Dr Calum Hamilton, Dr Sarah Lawley, Dr Gemma Roberts, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Introduction: Diagnostic criteria for prodromal dementia with Lewy bodies have recently been published. These include the use of imaging biomarkers to distinguish mild cognitive impairment with Lewy bodies (MCI-LB) from MCI due to other causes. Two potential biomarkers listed, though not formally included in the diagnostic criteria, due to insufficient evidence, are relatively preserved hippocampi, and atrophy of the insula cortex on structural brain imaging. Methods: In this report, we sought to investigate these imaging biomarkers in 105 research subjects, including well characterised groups of patients with MCI-LB (n=38), MCI with no core features of Lewy body disease (MCI-AD; n=36) and healthy controls (N=31). Hippocampal and insula volumes were determined from T1 weighted structural MRI scans, using grey matter segmentation performed with SPM software. Results: Adjusting for age, sex and intracranial volume, there were no differences in hippocampal or insula volume between MCI-AD and MCI-LB, although in both conditions volumes were significantly reduced relative to controls. Conclusion: Our results do not support the use of either hippocampal or insula volume to identify prodromal dementia with Lewy bodies.


Publication metadata

Author(s): Firbank MJ, Durcan R, O'Brien JT, Allan LM, Barker S, Ciafone J, Donaghy PC, Hamilton CA, Lawley S, Roberts G, Taylor JP, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Parkinsonism and Related Disorders

Year: 2021

Pages: epub ahead of print

Online publication date: 27/03/2021

Acceptance date: 11/03/2021

Date deposited: 12/03/2021

ISSN (print): 1353-8020

ISSN (electronic): 1873-5126

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.parkreldis.2021.03.011

DOI: 10.1016/j.parkreldis.2021.03.011


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Funding

Funder referenceFunder name
Alzheimer’s Research UK

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