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In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Lookup NU author(s): Dr Shelby BarnettORCiD

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Abstract

Thalidomide, a drug known for its teratogenic side-effects, is used successfully to treat a variety of clinical conditions including leprosy and multiple myeloma. Intense efforts are underway to synthesize and identify safer, clinically relevant analogs. Here, we conduct a preliminary in vivo screen of a library of new thalidomide analogs to determine which agents demonstrate activity, and describe a cohort of compounds with anti-angiogenic properties, anti-inflammatory properties and some compounds which exhibited both. The combination of the in vivo zebrafish and chicken embryo model systems allows for the accelerated discovery of new, potential therapies for cancerous and inflammatory condition

Publication metadata

Author(s): Beedie SL, Rore HM, Barnett S, Chau CH, Luo W, Greig NH, Figg WD, Vargesson N

Publication type: Article

Publication status: Published

Journal: Oncotarget

Year: 2016

Volume: 7

Issue: 22

Pages: 33237-33245

Online publication date: 22/04/2016

Acceptance date: 31/03/2016

Date deposited: 16/03/2021

ISSN (electronic): 1949-2553

Publisher: Impact Journals, LLC

URL: https://doi.org/10.18632/oncotarget.8909

DOI: 10.18632/oncotarget.8909

PubMed id: 27120781

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