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Lookup NU author(s): Dr Rachael LawsonORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration, composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessed with the MDS-UPDRS constipation item or a comparable categorical scale. Primary PD outcomes of interest were dementia, postural instability and death. PD patients were stratified according to constipation severity at diagnosis: none (n=313, 67.3%), minor (n=97, 20.9%) and major (n=55, 11.8%). Clinical progression to all 3 outcomes was more rapid in those with more severe constipation at baseline (Kaplan Meier survival analysis). Cox regression analysis adjusting for relevant confounders confirmed a significant relationship between constipation severity and dementia, but not postural instability or death. Early constipation may predict an accelerated progression of neurodegenerative pathology.
Author(s): Camacho M, Macleod AD, Maple-Grødem J, Evans JR, Breen DP, Cummins G, Wijeyekoon RS, Greenlan J, Alves G, Tysnes O, Lawson RA, Barker RA, Williams-Gray CH
Publication type: Article
Publication status: Published
Journal: npj Parkinson's Disease
Online publication date: 26/05/2021
Acceptance date: 26/02/2021
Date deposited: 17/03/2021
ISSN (electronic): 2373-8057
Publisher: Nature Research
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