Toggle Main Menu Toggle Search

Open Access padlockePrints

A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge

Lookup NU author(s): Dr James StachORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use. Natural products and their derivatives are, and will continue to be, an important source of these molecules. Sea sponges harbour a diverse microbiome that co-exists with the sponge, and these bacterial communities produce a rich array of bioactive metabolites for protection and resource competition. For these reasons, the sponge microbiota constitutes a potential source of clinically relevant natural products. To date, efforts in bioprospecting for these compounds have focused predominantly on sponge specimens isolated from shallow water, with much still to be learned about samples from the deep sea. Here we report the isolation of a new Micromonospora strain, designated 28ISP2-46T, recovered from the microbiome of a mid-Atlantic deep-sea sponge. Whole-genome sequencing reveals the capacity of this bacterium to produce a diverse array of natural products, including kosinostatin and isoquinocycline B, which exhibit both antibiotic and antitumour properties. Both compounds were isolated from 28ISP2-46T fermentation broths and were found to be effective against a plethora of multidrug-resistant clinical isolates. This study suggests that the marine production of isoquinocyclines may be more widespread than previously supposed and demonstrates the value of targeting the deep-sea sponge microbiome as a source of novel microbial life with exploitable biosynthetic potential.

Publication metadata

Author(s): Back CR, Stennett HL, Williams SE, Wang L, Ojeda Gomez J, Abdulle OM, Duffy T, Neal C, Mantell J, Jepson MA, Hendry KR, Powell D, Stach JEM, Essex-Lopresti AE, Willis CL, Curnow P, Race PR

Publication type: Article

Publication status: Published

Journal: Marine Drugs

Year: 2021

Volume: 19

Issue: 2

Online publication date: 11/02/2021

Acceptance date: 09/02/2021

Date deposited: 29/03/2021

ISSN (electronic): 1660-3397

Publisher: MDPI


DOI: 10.3390/md19020105

PubMed id: 33670308

Notes: Correction published on 28 March 2023


Altmetrics provided by Altmetric