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Lookup NU author(s): Professor Sarah O'Brien,
Dr Nicola HallORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Background: Campylobacter jejuni is the most common bacterial cause of human infectious intestinal disease.MethodsWe genome sequenced 601 human C. jejuni isolates, obtained from two large prospective studies of infectious intestinal disease (IID1 [isolates from 1993–1996; n = 293] and IID2 [isolates from 2008–2009; n = 93]), the INTEGRATE project [isolates from 2016–2017; n = 52] and the ENIGMA project [isolates from 2017; n = 163].ResultsThere was a significant increase in the prevalence of the T86I mutation conferring resistance to fluoroquinolone between each of the three later studies (IID2, INTEGRATE and ENIGMA) and IID1. Although the distribution of major multilocus sequence types (STs) was similar between the studies, there were changes in both the abundance of minority STs associated with the T86I mutation, and the abundance of clones within single STs associated with the T86I mutation.DiscussionFour population-based studies of community diarrhoea over a 25 year period revealed an increase over time in the prevalence of the T86I amongst isolates of C. jejuni associated with human gastrointestinal disease in the UK. Although associated with many STs, much of the increase is due to the expansion of clones associated with the resistance mutation.
Author(s): Haldenby S, Bronowski C, Nelson C, Kenny J, Martinez-Rodriguez C, Chaudhuri R, Williams NJ, Forbes K, Strachan NJ, Pulman J, Winstanley IN, Corless CE, Humphrey TJ, Bolton FJ, O'Brien SJ, Hall N, Hertz-Fowler C, Winstanley C
Publication type: Article
Publication status: Published
Journal: PLoS ONE
Online publication date: 30/01/2020
Acceptance date: 20/12/2019
Date deposited: 24/05/2021
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
PubMed id: 31999701
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