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The Synthesis of Biarylmonophosphonates via Palladium-Catalysed Phosphonation, Iridium-Catalysed C-H Borylation and Palladium-Catalysed Suzuki-Miyaura Coupling

Lookup NU author(s): Dr Simon DohertyORCiD, Dr Julian Knight, Tina Tran, Daniel Perry



This is the authors' accepted manuscript of an article that has been published in its final definitive form by Springer, 2022.

For re-use rights please refer to the publisher's terms and conditions.


The iridium-catalyzed C-H borylation of 3-substituted arylphosphonates with B2pin2 affords the corresponding meta-phosphonate substituted arylboronic esters exclusively which have been used as nucleophilic reagents in a subsequent palladium-catalyzed Suzuki-Miyaura cross-coupling to generate a range of biarylmonophosphonates. Gratifyingly, the Suzuki-Miyaura cross-coupling can be conducted without purifying the boronic ester which greatly simplifies the synthetic procedure.

Publication metadata

Author(s): Doherty S, Knight JG, Tran TST, Perry DO

Publication type: Article

Publication status: Published

Journal: Catalysis Letters

Year: 2022

Volume: 152

Pages: 398-413

Online publication date: 07/05/2021

Acceptance date: 25/04/2021

Date deposited: 27/04/2021

ISSN (print): 1011-372X

ISSN (electronic): 1572-879X

Publisher: Springer


DOI: 10.1007/s10562-021-03643-3


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