Toggle Main Menu Toggle Search

Open Access padlockePrints

Trajectories of pain over six years in early Parkinson’s disease: ICICLE-PD

Lookup NU author(s): Dr Jenni Naisby, Dr Rachael Lawson, Dr Brook Galna, Dr Lisa Alcock, Professor David Burn, Professor Lynn Rochester, Dr Alison Yarnall

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Pain is a common non-motor symptom in Parkinson’s disease (PD), affecting up to 85% of patients. The frequency and stability of pain over time has not been extensively studied. There is a paucity of high-quality studies investigating pain management in PD. In order to develop interventions, an understanding of how pain changes over the disease course is required.Methods: 154 participants with early PD and 99 age-and-sex-matched controls were recruited as part of a longitudinal study (Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in PD, ICICLE-PD). Pain data was collected at 18-month intervals over 72 months in both groups using the Nonmotor Symptom Questionnaire (NMSQ), consisting of a binary yes/no response. Two questions from the Parkinson’s Disease Questionnaire (PDQ-39) were analysed for the PD group only.Results: Unexplained pain was common in the PD group and occurred more frequently than in age-matched controls. ‘Aches and pains’ occurred more frequently than ‘cramps and muscle spasms’ at each time point (p<0.001) except 54 months.Conclusions: This study shows that pain is prevalent even in the early stages of PD, yet the frequency and type of pain fluctuates as symptoms progress. People with PD should be asked about their pain at clinical consultations and given support with describing pain given the different ways this can present.


Publication metadata

Author(s): Naisby J, Lawson RA, Galna B, Alcock L, Burn DJ, Rochester L, Yarnall AJ

Publication type: Article

Publication status: Published

Journal: Journal of Neurology

Year: 2021

Pages: epub ahead of print

Online publication date: 27/04/2021

Acceptance date: 24/04/2021

Date deposited: 27/04/2021

ISSN (print): 0340-5354

ISSN (electronic): 1432-1459

Publisher: Springer

URL: https://doi.org/10.1007/s00415-021-10586-7

DOI: 10.1007/s00415-021-10586-7


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share