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Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials

Lookup NU author(s): Dr Barbara Gregson, Emeritus Professor David Mendelow


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© Congress of Neurological Surgeons 2021.BACKGROUND: The extent of intracerebral hemorrhage (ICH) removal conferred survival and functional benefits in the minimally invasive surgery with thrombolysis in intracerebral hemorrhage evacuation (MISTIE) III trial. It is unclear whether this similarly impacts outcome with craniotomy (open surgery) or whether timing from ictus to intervention influences outcome with either procedure. OBJECTIVE: To compare volume evacuation and timing of surgery in relation to outcomes in the MISTIE III and STICH (Surgical Trial in Intracerebral Hemorrhage) trials. METHODS: Postoperative scans were performed in STICH II, but not in STICH I; therefore, surgical MISTIE III cases with lobar hemorrhages (n = 84) were compared to STICH II all lobar cases (n = 259) for volumetric analyses. All MISTIE III surgical patients (n = 240) were compared to both STICH I and II (n = 722) surgical patients for timing analyses. These were investigated using cubic spline modeling and multivariate risk adjustment. RESULTS: End-of-treatment ICH volume ≤28.8 mL in MISTIE III and ≤30.0 mL in STICH II had increased probability of modified Rankin Scale (mRS) 0 to 3 at 180 d (P = .01 and P = .003, respectively). The effect in the MISTIE cohort remained significant after multivariate risk adjustments. Earlier surgery within 62 h of ictus had a lower probability of achieving an mRS 0 to 3 at 180 d with STICH I and II (P = .0004), but not with MISTIE III. This remained significant with multivariate risk adjustments. There was no impact of timing until intervention on mortality up to 47 h with either procedure. CONCLUSION: Thresholds of ICH removal influenced outcome with both procedures to a similar extent. There was a similar likelihood of achieving a good outcome with both procedures within a broad therapeutic time window.

Publication metadata

Author(s): Polster SP, Carrion-Penagos J, Lyne SB, Gregson BA, Cao Y, Thompson RE, Stadnik A, Girard R, Money PL, Lane K, McBee N, Ziai W, Mould WA, Iqbal A, Metcalfe S, Hao Y, Dodd R, Carlson AP, Camarata PJ, Caron J-L, Harrigan MR, Zuccarello M, Mendelow AD, Hanley DF, Awad IA

Publication type: Article

Publication status: Published

Journal: Neurosurgery

Year: 2021

Volume: 88

Issue: 5

Pages: 961-970

Print publication date: 01/05/2021

Online publication date: 20/01/2021

Acceptance date: 12/11/2020

ISSN (print): 0148-396X

ISSN (electronic): 1524-4040

Publisher: Oxford University Press


DOI: 10.1093/neuros/nyaa572

PubMed id: 33475732


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