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Lookup NU author(s): Dr Lei HuangORCiD, Emeritus Professor Andrew MellorORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© American Federation for Medical Research 2021. No commercial re-use. See rights and permissions. Published by BMJ.Immune activation complicates HIV despite antiretroviral therapy (ART). Indoleamine 2,3 dioxygenase (IDO) catabolizes tryptophan (T) to kynurenine (K), regulating immune activity, and IDO activity increases with age. This study examines the relationship of IDO activity, bacterial translocation, and aging in people living with HIV (PLWH) on ART. Samples and data from PLWH on ART from the Centers for AIDS Research Network of Integrated Clinical Systems and from matched HIV-uninfected patients (controls) from the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study were analyzed. The ratio of K to T (K:T) and neopterin were indicators of inflammation; 16S ribosomal DNA (16S rDNA) and lipopolysaccharide (LPS) were markers of bacterial translocation. Samples and data from 205 PLWH and 99 controls were analyzed. PLWH had higher K:T values across all ages, with a significant relationship between age and K:T for both groups. CD4 count or CD4 nadir had no association with K:T. There was no positive association between level of 16S rDNA or LPS detection and K:T. K:T and neopterin were associated. PLWH had elevated IDO activity, at younger ages, despite ART. This study suggests K:T ratio increases with age in both groups and is elevated in PLWH at all ages compared with age-matched controls.
Author(s): Baer SL, Colombo RE, Johnson MH, Wakade S, Pacholczyk G, Newman-Whitlow C, Thompson SA, Saag MS, Martin JN, Floris-Moore M, Huang L, Mellor AL
Publication type: Article
Publication status: Published
Journal: Journal of Investigative Medicine
Year: 2021
Volume: 69
Issue: 6
Pages: 1238-1244
Print publication date: 01/08/2021
Online publication date: 01/08/2021
Acceptance date: 23/03/2021
Date deposited: 02/07/2021
ISSN (print): 1081-5589
ISSN (electronic): 1708-8267
Publisher: BMJ Publishing Group
URL: https://doi.org/10.1136/jim-2021-001794
DOI: 10.1136/jim-2021-001794
PubMed id: 33875612
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