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Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men

Lookup NU author(s): Emerita Professor Julia Newton



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© Copyright © 2021 Pawłowski, Buszko, Newton, Kujawski and Zalewski.The purpose of this study is to assess the cardiovascular system response to orthostatic stress in a group of 133 healthy men using heart rate asymmetry (HRA) methods. HRA is a feature of variability in human heart rate which is dependent upon external and internal body conditions. The initial phases of head-up tilt test (HUTT), namely, supine and tilt, were chosen as the external body affecting factors. Various calculation methods of HRA, such as Porta’s index (PI), Guzik’s index (GI), and its variance based components, were used to assess the heart rate variability (HRV) and its asymmetry. We compared 5-min ECG recordings from both supine and tilt phases of HUT test. Short-term HRA was observed in 54.1% of men in supine phase and 65.4% of men in tilt phase. The study revealed significant increase of GI (from 0.50 to 0.52, p < 0.001) in the tilt phase as well as significant changes in HRV descriptors between HUTT phases. Our results showed that the variability of human heart rate and its asymmetry are sensitive to orthostatic stress. The study of short-term HRA is a potential additional tool to increase sensitivity in conditions where HUTT is a diagnostic tool, such as vasovagal syncope.

Publication metadata

Author(s): Pawlowski R, Buszko K, Newton JL, Kujawski S, Zalewski P

Publication type: Article

Publication status: Published

Journal: Frontiers in Physiology

Year: 2021

Volume: 12

Online publication date: 13/04/2021

Acceptance date: 22/03/2021

Date deposited: 17/05/2021

ISSN (electronic): 1664-042X

Publisher: Frontiers Media S.A.


DOI: 10.3389/fphys.2021.657902


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