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Functional connectivity in mild cognitive impairment with Lewy bodies

Lookup NU author(s): Julia SchumacherORCiD, Professor John-Paul TaylorORCiD, Dr Calum Hamilton, Dr Michael FirbankORCiD, Dr Paul Donaghy, Dr Gemma RobertsORCiD, Dr Louise Allan, Dr Rory Durcan, Nicola Barnett, Professor John O'Brien, Professor Alan ThomasORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021, The Author(s). Previous resting-state fMRI studies in dementia with Lewy bodies have described changes in functional connectivity in networks related to cognition, motor function, and attention as well as alterations in connectivity dynamics. However, whether these changes occur early in the course of the disease and are already evident at the stage of mild cognitive impairment is not clear. We studied resting-state fMRI data from 31 patients with mild cognitive impairment with Lewy bodies compared to 28 patients with mild cognitive impairment due to Alzheimer’s disease and 24 age-matched controls. We compared the groups with respect to within- and between-network functional connectivity. Additionally, we applied two different approaches to study dynamic functional connectivity (sliding-window analysis and leading eigenvector dynamic analysis). We did not find any significant changes in the mild cognitive impairment groups compared to controls and no differences between the two mild cognitive impairment groups, using static as well as dynamic connectivity measures. While patients with mild cognitive impairment with Lewy bodies already show clear functional abnormalities on EEG measures, the fMRI analyses presented here do not appear to be sensitive enough to detect such early and subtle changes in brain function in these patients.

Publication metadata

Author(s): Schumacher J, Taylor J-P, Hamilton CA, Firbank M, Donaghy PC, Roberts G, Allan L, Durcan R, Barnett N, O'Brien JT, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Journal of Neurology

Year: 2021

Volume: 268

Pages: 4707-4720

Print publication date: 01/12/2021

Online publication date: 29/04/2021

Acceptance date: 24/04/2021

Date deposited: 10/06/2021

ISSN (print): 0340-5354

ISSN (electronic): 1432-1459

Publisher: Springer Nature


DOI: 10.1007/s00415-021-10580-z

PubMed id: 33928432


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Funder referenceFunder name
Alzheimer’s Research UK (ARUK-PG2015-13)
NIHR Newcastle Biomedical Research Centre (Grant numbers BH120812 and BH120878)