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Lookup NU author(s): Isaline Castan,
Professor Mike Waring
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
DNA-encoded libraries (DELs) are becoming an established technology for finding ligands for protein targets. We have abstracted and analysed libraries from the literature to assess the synthesis strategy, selections of reactions and monomers and their propensity to reveal hits. DELs have led to hit compounds across a range of diverse protein classes. The range of reactions and monomers utilised has been relatively limited and the hits are often higher in molecular weight than might be considered ideal. Considerations for future library designs with reference to chemical diversity and lead-like properties are discussed.
Author(s): Castan IFSF, Graham JS, Salvini CLA, Stanway-Gordon HA, Waring MJ
Publication type: Article
Publication status: Published
Journal: Bioorganic and Medicinal Chemistry
Print publication date: 01/08/2021
Online publication date: 10/06/2021
Acceptance date: 04/06/2021
Date deposited: 08/07/2021
ISSN (print): 0968-0896
ISSN (electronic): 1464-3391
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