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Lookup NU author(s): Professor Muzlifah Haniffa, Dr Bayanne Olabi, Dr Roser Vento-Tormo, Dr Simone Webb
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Springer Nature, 2021.
For re-use rights please refer to the publisher's terms and conditions.
The Human Developmental Cell Atlas (HDCA) initiative, part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understand normal organogenesis, the impact of mutations, environmental factors and infectious agents on human development, its relevance to congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. In this perspective, we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies in order to create a reference atlas across gestation. Like the Human Genome Project, the HDCA project will integrate the output from a growing community of scientists mapping human development into a unified atlas. We describe the early milestones achieved and the use of human stem cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.
Author(s): Haniffa M, Taylor D, Linnarsson S, Aronow BJ, Bader GD, Barker RA, Camara PG, GrayCamp J, Chédotal A, Copp A, Etchevers HC, Giacobini P, Göttgens B, Guoji G, Hupalowska A, James KR, Kirby E, Kriegstein A, Lundeberg J, Marioni JC, Meyer KB, Niakan KK, Nilsson M, Olabi B, Pe'er D, Regev A, Rood J, Rozenblatt-Rosen O, Satija R, Teichmann SA, Treutlein B, Vento-Tormo R, Webb S, Developmental Biological Network HCA
Publication type: Article
Publication status: Published
Journal: Nature
Year: 2021
Volume: 597
Pages: 196-205
Online publication date: 08/09/2021
Acceptance date: 07/05/2021
Date deposited: 22/06/2021
ISSN (print): 0028-0836
ISSN (electronic): 1476-4687
Publisher: Springer Nature
URL: .ttps://doi.org/10.1038/s41586-021-03620-1
DOI: 10.1038/s41586-021-03620-1
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